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A tablet is a mixture of active substances and excipients, usually in powder form, pressed or compacted into a solid.
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The excipients include binders, glidants (flow aids) and lubricants to ensure efficient tabletting;
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disintegrants to ensure that the tablet breaks up in the digestive tract;
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sweetners or flavours to mask the taste
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of bad-tasting active ingredients;and pigments to make uncoated tablets visually attractive.
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A coating may be applied to hide the taste of the tablet's components,
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to make the tablet smoother and easier to swallow, and to make it more resistant
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to the environment, extending its shelf life.Medicines to be taken orally are very often supplied in tablet form;
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indeed the word tablet without qualification would be taken to refer to a medicinal tablet.
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Medicinal tablets and capsules are often called pills.Other products are manufactured in the form of
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tablets which are designed to dissolve or disintegrate;e.g. cleaning and deodorizing products.
Medicinal tablets are usually intended to be swallowed, and are of a suitable size and shape.
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Tablets for other purposes, e.g., effervescent medicinal tablets and non-medicinal tablets, may be larger.
Medicinal tablets were originally made in the shape of a disk of whatever color their
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components determined, but are now made in many shapes and colors to help users to distinguish between different medicines that they take.
Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified.Sizes of tablets to be
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swallowed range from a few millimeters to about a centimeter.Some tablets are in the shape
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of capsules, and are called "caplets".When Tylenol capsules were laced with
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cyanide (an incident referred to as the Tylenol scare),
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many people stopped buying capsules because they are easy to contaminate,
in favor of tablets, which are not. Some makers of
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over-the-counter drugs responded by starting to make what they termed "caplets",
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which were actually just tablets made in the shape of a capsule.
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Tablets are often scored to allow them to be easily broken into
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equal halves for smaller doses.
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Some people have difficulty swallowing tablets,
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this is called dysphagia. This is often caused by a gag reflex.
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In the tablet-pressing process, it is important that all
ingredients be fairly dry, powdered or granular, somewhat uniform in particle size, and freely flowing.
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Mixed particle sized powders can segregate due to operational vibrations, which can result in
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tablets with poor drug or active pharmaceutical ingredient (API)
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content uniformity.Content uniformity ensures that the same
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API dose is delivered with each tablet.Some APIs may be tableted as pure
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substances, but this is rarely the case;most formulations include excipients.
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Normally, an inactive ingredient (excipient) termed a binder is
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added to help hold the tablet together and give it strength.
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A wide variety of binders may be used, some common ones including
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lactose powder, dibasic calcium phosphate, sucrose, corn (maize) starch,
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microcrystalline cellulose and modified cellulose (for example hydroxymethyl cellulose).
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Often, an ingredient is also needed to act as a disintegrant
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that hydrates readily in water to aid tablet dispersion once swallowed,